What is Ankylosing Spondylitis?

Health News

Ankylosing spondylitis (AS) is a chronic, progressive, painless rheumatic disease that affects the spine. The diagnosis is made according to the Modified New York criteria. Pain in AS can be reduced or even disappeared by movement, sitting for a long time increases with rest. Patients are more painful in the mornings and have limited spinal movements, reducing pain and limitation later in the day.

The first symptoms in AS may be waist, hip and heel pain. If the disease is not treated properly, spinal deformities and hunchback occur in later periods.

Genetic susceptibility is a known feature of AS. The HLA-B27 tissue antigen is 95% white in the white race and 50% in the African black. The risk of developing HLA B27 positive AS in children with HLA-B27 positive is 25%. In other words, there may be more than one ASL in the family.

What is the incidence?

The incidence varies between 0.1-1.4%. It is seen as 0.04% in Japanese and 6% in Haida Indians. Considering that the average frequency of 0.5% in our country is unknown, although incidence rate in Turkey is said to be about 300-350 thousand ankylosing spondylitis. It is seen 3 times more than males in females.

Are factors such as climate, age and gender effective?

It is said that climate and environmental conditions may affect symptoms (such as pain, limitation of movement) but these are not the cause of AS.

It usually comes out at an early age. Why is that?

Although it is known that AS can start between the ages of 8-45, it is determined that it starts between 15-30 years of age and most frequently it is 24 years old. It is not known why he started at a young age.

Do you have any treatment? Is it possible to stop?

It is not possible to fully heal. Disease activity can be reduced and development can be slowed down with current treatment methods. Early diagnosis Non-steroidal anti-inflammatory drugs should be used in the treatment. Regular exercises should be done. Anti TNF alpha therapy (such as Enbrel), which is one of the last treatment modalities in our country, is a big hope in stopping the progression of the disease.

Which sections are most common in patients? How does it affect life?

AS is mostly the spine (at all levels) and the sacroiliac joint (the joint with the pelvis of the spine), then holds the large joints like the hip and shoulder. Hand and foot joints are very rare. The expansion of the thoracic cage is very low, resulting in respiratory problems.

In addition to musculoskeletal system, there may also be extra-articular involvement of the eye, kidney and aorta. At least one time in the life of the patients at least one episode of acute uveitis.

Although the development of the disease changes from person to person, people who do heavy bodily work, permanent load carriers need to adjust their working style even if the disease is mild, if they require to be leaning forward and heavy lifting, they should change their jobs.

The fact that women with AS are not able to use medication during pregnancy and the increase in body weight may increase the limitation and pain in their movements. Patients should continue to exercise regularly according to pregnancy.

Leave a reply